Keith Dunnington, 54, a nurse for more than 30 years, died at his parents home in South Shields on 19 April.
His mother Lillian, 81, died on 1 May and her husband Maurice, 85, died days later at South Tyneside Hospital.
Keith’s cousin Debbie Harvey said her family was heartbroken but praised the “absolutely amazing” NHS staff who “could not do enough” for the family.
She said front-line hospital staff pushed Mr and Mrs Dunnington’s beds together so they could hold hands.
Dad-of-two Keith, who passed away last month, worked at the Queen Elizabeth Hospital in Gateshead.
Yvonne Ormston MBE, chief executive of Gateshead Health NHS Foundation Trust, said he was “a popular and hard-working” nurse.