Thousands of EasyJet and Virgin airline staff are being offered work in the new NHS Nightingale Hospital.
Those who sign up will support nurses and senior clinicians at the coronavirus field hospital in east London, the NHS said.
Virgin Atlantic said furloughed staff who help will be paid through the government retention scheme.
NHS England said many airline staff are first aid trained and already have security clearance.
The workers will be changing beds and performing other non-clinical tasks and helping doctors and nurses working on the wards, the NHS said.
Virgin Atlantic said it has written to around 4,000 employees, while EasyJet said it has contacted 9,000 of its UK-based staff – half of whom are first aid trained, the airline said.