In the March 5th episode entitled “Leave a Light On,” Chambers’ longtime character revealed in a heartfelt letter that he has reunited with Izzie Stevens (Katherine Heigl), one of the original interns of the series and Alex’s ex-wife. In letters sent to his current wife Jo (Camilla Luddington), Miranda (Chandra Wilson) and Meredith (Ellen Pompeo), Alex explained that he found Izzie and learned that she had his kids. So he decided to stay and make up for the five years he lost with them by raising them now.
“It is nearly impossible to say goodbye to Alex Karev. That is as true for me and for all of the writers at ‘Grey’s Anatomy,’ as it is for the fans,” said showrunner Krista Vernoff in a statement. “We have loved writing Alex. And we have loved watching Justin Chambers’ nuanced portrayal of him. For 16 seasons, 16 years, we have grown up alongside Alex Karev. We have been frustrated by his limitations and we have been inspired by his growth and we have come to love him deeply and to think of him as one of our very best friends. We will miss him terribly. And we will always be grateful for his impact, on our show, on our hearts, on our fans, on the world.”